DGNM-Jahrestagung 2022

Die Jahrestagung 2022 der Deutschen Gesellschaft für Neurogastroenterologie und Motilität e.V. fand vom 25. - 27. Februar 2022 als Online-Veranstaltung statt. Es war eine große Freude, viele Gäste zu einem ganz besonderen Programm begrüßen zu können. Highlight: das Abschiedssymposium für Michael Schemann mit vielen prominenten Gästen!

Report

Jahrestagung 2022 online

80 participants from different disciplines joined the 29th annual meeting of the German Society of Neurogastroenterology and Motility (DGNM) from February 26 to 27, 2022. Because of ongoing restrictions due to the SARS-COV2 pandemic, the meeting took place online.

During the 29th annual meeting, 31 talks were given in eleven sessions. These were dedicated to basic and translational science (Basic: ENS; Translational: brain stimulation and regulation of food intake / pancreas / motility) and clinical science (diagnostics / IBS / update current guidelines), and most were given by youngsters, who reported on their ongoing projects. Saturday afternoon was dedicated to a Farewell Symposium for Professor Michael Schemann. In honour of his outstanding work as a scientist and academic teacher, renowned scientists from all over the world and close collaborators gave state of the art lectures on the importance of Neurogastroenterology for other disciplins and recognized Michael Schemann’s contributions to the field. Personal contributions underlined his importance as a mentor.

Prof. Michael Schemann, TU München

At the general assembly on Saturday evening, members of the society were updated on the activities of the national and international societies. Timelines and meeting formats of upcoming symposia were presented as well as current and potential future opportunities to join ESNM-driven studies on disorders of the gut brain axis. First results of the working groups, which had been established in 2021, for the improvement of teaching (Robert Patejdl), young academics and digital future (Peter Neckel) of Neurogastroenterology were presented.

Dr. Khasanov, Ms. Evers and Dr. Schmitteckert were awarded with a Martin Wienbeck Travel Grant to attend the Development of ENS Meeting to take place in Ferrara, Italy and the Europhysiology Meeting in Kopenhagen, Denmark, respectively.

Following two more sessions with scientific presentations on Sunday morning, the meeting was concluded by three lectures on current guidelines (functional dyspepsia, intestinal motility disorders, irritable bowel syndrome).

The next meeting will take place in Berlin from March 3rd to March 5th, 2023.

Programm zur Jahrestagung 2022

25. - 27. Februar 2022

FREITAG, 25. Februar 2022

19.00 – 20.00 Virtuelle After-Work-Lounge

SAMSTAG, 26. Februar 2022

8.00 Eröffnung / Begrüßung (A Stengel, Tübingen/Berlin)

Session I:
Basic - ENS (Vorsitz: G Mazzuoli-Weber, Hannover)

8.00 – 8.15 Recordings from gastric mechanosensitive neurons (S Mayr, R Schliep, G Mazzuoli-Weber, Hannover)
8.15 – 8.30 Elucidating the role of the NF-kB pathway on the enteric neural system (M A Tapia-Laliena, *R Khasanov, L M Wessel, M Böttcher, K-H Schäfer, Mannheim)
8.30 – 8.45 Impact of the environment on ENS and muscle cells in artificially constructed functional muscle fibers in Vitro (*R Khasanov, M A Tapia-Laliena, M Böttcher, L Wessel, K-H Schäfer, Mannheim, Zweibrücken)
8.45 – 9.00 Wnt antagonist Dickkopf1: regulator of the enteric progenitor niche in mice and human (M Scharr, M Fischer, S Scherer, P Neckel (Tübingen)

Session II:
Translational - Brain Stimulation and Regulation of Food Intake (Vorsitz: M Goebel-Stengel, Rottweil/Tübingen)

9.00 – 9.15 Surgical stress stimulates the activity of several phoenixin-immunoreactive brain nuclei (T Friedrich, M A Schalla, M Goebel-Stengel, P Kobelt, M Rose, A Stengel, Berlin, Rottweil, Tübingen)
9.15 – 9.30 Vagus nerve stimulation increases stomach-brain coupling via a vagal afferent pathway (S Müller, V Teckentrup, I Rebollo, M Hallschmid, N Kroemer, Tübingen, Nuthetal)
9.30 – 9.45 Food intake microstructure of rats in the novel chronic activity-based anorexia model (M A Schalla, V Hanel, T Friedrich, M Goebel-Stengel, P Kobelt, M Rose, A Stengel, Berlin, Rottweil, Tübingen)
09.45 – 10.00 Anxiety and anhedonia in a chronic activity-based anorexia model (V Hanel, M A Schalla, T Friedrich, M Goebel-Stengel, M Long, P Kobelt, M Rose, A Stengel, Berlin, Rottweil, Tübingen)
10.00 – 10.15 Kaffeepause

Session III:
Translational - Pancreas (Vorsitz: R Patejdl, Rostock)

10.15 – 10.30 Neuronal glutamate promotes pancreatic cancer cell migration through neuro-cancer synapses that fuel the GRIN2D-EZH2-E2F1-RB pathway (L Ren, München)
10.30 – 10.45 Synergic crosstalk between intratumoral nerves and myeloid derived suppressor cells in pancreatic cancer via neuronal-derived expression of CXCL8. (C Mota Reyes, T Zwick, A Muckenhuber, W Weichert, H Friess, H Algül, R Istvanffy, I E Demir, München)
10.45 – 11.00 Neoadjuvant chemotherapy suppresses immune function and favours neuronal activity in patients with pancreatic ductal adenocarcinoma (M Kießler, C Mota Reyes, H Friess, R Istvanffy, I E Demir, München)
11.00 – 11.15 Pancreatic proteases mediate pain in pancreatic cancer (P Gärtner, O Safak, D Jungwirth, S Tokalov, H Friess, R Istvanffy, I E Demir, München)
11.15 – 11.30 The pancreatic proteases as new analgesic targets in acute and chronic pancreatitis (O Safak, D Jungwirth, P Gärtner, S Tokalov, H Friess, I E Demir, München)

Session IV:
Vortrag Preisträgerin Neurogastroenterologie (Vorsitz: T Frieling, Krefeld)

11.30 – 12.00 Autoreactive CD8 T cell-mediated attack of enteric neurons induces gastrointestinal dysmotility (M Sanchez-Ruiz, Köln)
12.00 – 13.00 Mittagspause

Session V:
Clinical - Diagnostics (Vorsitz: A Stengel, Tübingen, Berlin)

13.00 – 13.15 Neurogastroenterologic disorders and immune mediated food intolerance within the duodenum – evaluation by endomicroscopy (T Frieling, B Gjini, I Melchior, C Kreysel, P Euler, D Müller, M Blank, Krefeld)
13.15 – 13.30 Eosinophilic esophagitis and food challenge – evaluation throug endomicroscopys (T Frieling, B Gjini, I Melchior, C Kreysel, P Euler, D Müller, M Blank, Krefeld)

Farewell-Symposium for Prof. Michael Schemann

Session VI:
Importance of Neurogastroenterology for other disciplines (Vorsitz: T Wedel, Kiel)

13.30 – 14.00 Neurogastroenterology and Nutritional Physiology (Hannelore Daniel, Freising)
14.00 – 14.30 Neurogastroenterology and Neurophysiology (David Grundy, Sheffield, UK)
14.30 – 15.00 Neurogastroenterology and Neurology (Michel Neunlist, Nantes, France)
15.00 – 15.30 Neurogastroenterology andNeuroendocrinology (Y Taché, Los Angeles, USA)
15.30 – 16.00 Kaffeepause

Session VII:
The good old days: from Hohenheim to Freising - a Cologne in exile (Vorsitz: P Enck, Tübingen/Berlin)

16.00 – 16.30 Sabine Bühner – Paul Enck – Thomas Frieling – Michel Neunlist –
Klaus Michel – Helga Pfannkuche – Gemma Mazzuoli-Weber –
Holger Sann

Session VIII:
Neurogastroenterology: Love relationship or marriage of convenience? (Vorsitz: M Camilleri, Rochester, USA)

16.30 – 17.30 A debate between basic research and clinical relevance Roberto de Giorgio (Ferrara, Italy) und Simon Brookes (Adelaide, Australia)
17.30 – 18.00 Pause
18.00 – 20.00 Mitgliederversammlung
ab 20.00 Geselliges „Biereinander“ in der virtuellen Korbiniansklause

Sonntag, 27. Februar 2022

Session IX:
Translational - Motility (Vorsitz: M Sanchez-Ruiz, Köln)

9.00 – 9.15 Murine esophagus expresses glial-derived central nervous system antigens (J Wörl, C Kapitza, R Chunder, A Scheller, K S Given, W B Macklin, M Enders, S Kürten, W L. Neuhuber, Erlangen, Bonn, Homburg, Aurora, USA)
9.15 – 9.30 Fennel tea shows region specific effects on stomach motility (A Annahazi, M Schemann, Freising)
9.30 – 9.45 Sphingosine-1-phosphate agonists as modulators of gastric and intestinal contractility: signaling pathways and potential interactions with immune cells (*A Evers, V Wendel, R Patejdl, Rostock)
9.45 – 10.00 Identification and characterization of novel candidate genes in familial Hirschsprung Disease (*S Schmitteckert, D Dawid, T Mederer, L Carstensen, R Röth, P Günther, G A. Rappold, P Romero, B Niesler, Heidelberg)
10.00 – 10.15 Kaffeepause

Session X:
Basic & Clinical - IBS (Vorsitz: C Pehl, Vilsbiburg)

10.15 – 10.30 STW 5 affects growth and biofilm formation of selected members of gut microbiota (MT Khayyal, Kairo, Egypt)
10.30 – 10.45 Common molecular targets of the irritable bowel syndrome and of STW 5-II and their regulation (G Ulrich-Merzenich, A Shcherbakova, O Kelber, R M Ammar, Bonn, Darmstadt)
10.45 – 11.00 The herbal preparation STW 5 affects serotonergic pathways along the brain gut axis in irritable bowel syndrome (M T Khayyal, R M. Mohsen, N G. Gamal, Kairo, Egypt)
11.00 – 11.15 App-based digital treatment for irritable bowel syndrome to reduce symptoms and improve quality of life: A retrospective real-world evidence study (L Weißer, D Zhao, S Ballou, J Brinkmann, J Nee, M Storr, A Lembo, Berlin, Boston, USA)
11.15 – 11.30 Impact of the Covid-19 pandemic on the anxiety of patients with functional GI symptoms (M Goebel-Stengel, J Lohmiller, N Schäffeler, S Zipfel, A Stengel, Rottweil, Tübingen)
11.30 – 11.45 Kaffeepause

Session XI:
Clinical – Update current guidelines (Vorsitz: I E Demir, München)

11.45 – 12.00 Functional dyspepsia (M Storr, Starnberg)
12.00 – 12.15 Intestinal Motility Disorders (J Keller, Hamburg)
12.15 – 12.30 Irritable Bowel Syndrome (V Andresen, Hamburg)
12.30 Verabschiedung (A Stengel, Tübingen/Berlin)
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Titelbild-Wettbewerb 2022

Herzlichen Glückwunsch!

Christopher Kapitza, Doktorand bei Prof. Dr. med. Jürgen Wörl, Institut für Anatomie an der Universität Erlangen-Nürnberg, ist der diesjährige Gewinner unseres Wettbewerbs "Bestes Titelbild DGNM-Jahrestagung“.

Herr Kapitza beschäftigt sich in seiner Promotion mit der Darstellung von Gliazellen im Ösophagus von Maus und Mensch, um mögliche Angriffsziele bei Multipler Sklerose (MS) im Ösophagus genauer zu definieren. Periphere Angriffsziele bei MS rücken in den letzten Jahren immer mehr in den Vordergrund. Dysphagien sind bei MS ein ernstes Problem, insbesondere im fortgeschrittenem Verlauf der Erkrankung. Seine ersten Ergebnisse in der Maus wurden im Frühjahr 2021 hochrangig publiziert (International Journal of Molecular Sciences; Impact 5.9). Aus dieser Arbeit stammt das Titelbild, das in einer Zweifachfärbung ein Netzwerk von enterischen Gliazellen im Ösophagus von transgenen Mäusen (PLP-CreERT2 x Rosa26-tdTomato) zeigt. Über Injektion von Tamoxifen wurde die Expression eines roten Farbstoffes (tdTomato) induziert, der PLP-positive Gliazellen anzeigt (rot). Dieses Signal wurde mit einem sekundären Antikörper verstärkt (gelb). Diese enterischen Gliazellen wurden in dieser netzartigen Anordnung im Ösophagus noch nie vorher beobachtet.

Wir gratulieren Herrn Kapitza zu dieser sehr gelungenen Aufnahme. Als Sieger wird er kostenlos an der DGNM-Tagung 2022 teilnehmen.